Alexo Therapeutics Initiates ALX148 Clinical Trial Combination Cohorts for the Treatment of Patients with Advanced …


DUBLIN & BURLINGAME, Calif.–()–Alexo
Therapeutics
, a clinical-stage immuno-oncology company developing
therapies to block the CD47 checkpoint mechanism, today announced it has
initiated ALX148 combination dosing with targeted antibody therapies in
its Phase 1 clinical program in patients with advanced solid tumors and
lymphoma. The Company will present updated data on ALX148 at the 2018
American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago,
IL.

Poster Presentation Information
Title: A
Phase 1 Study of ALX148, a CD47 Blocker, Alone and in Combination with
Established Anti-Cancer Antibodies in Patients with Advanced Malignancy
and Non-Hodgkin Lymphoma

Session Name: Developmental
Therapeutics-Immunotherapy
Session Date: June 04, 2018
Presentation
Time:
8:00am – 11:30am CT
Abstract Number: 3068

“The initiation of ALX148 combination cohorts marks the next important
milestone in Alexo’s development,” said Sophia Randolph M.D., Ph.D.,
Chief Medical Officer of Alexo Therapeutics. “ALX148 is designed to
enhance the efficacy of antibody-based therapies, while avoiding the
dose-limiting toxicities that have been seen with other CD47-targeted
approaches in the clinic. ALX148 is generally well tolerated in patients
with advanced tumors and exhibits favorable pharmacokinetics and CD47
target occupancy at doses evaluated. No maximum tolerated dose of ALX148
was reached. With broad therapeutic potential across many types of
cancer, we are eager to now be evaluating ALX148 in combination with
select anti-cancer therapeutic antibodies.”

The ALX148 Phase 1 clinical trial is a two-part study that evaluates the
safety, pharmacokinetics, and pharmacodynamics of ALX148. Enrollment to
the single-agent dose escalation phase is complete and the combination
therapy portion in which ALX148 is administered with approved
anti-cancer antibodies is ongoing. Clinical data will be presented at
the ASCO 2018 Annual Meeting. For more information about the Phase 1
study, please visit clinicaltrials.gov,
identifier number NCT03013218.

About ALX148
ALX148 is a fusion protein comprised of an
engineered high affinity CD47 binding domain of SIRPα linked to an
inactive Fc region of human immunoglobulin. ALX148 potently and
specifically binds CD47 and blocks its interaction with SIRPα, thus
inhibiting a key immune checkpoint mechanism exploited by cancer
cells. In preclinical studies, ALX148 bridges innate and adaptive
immunity to enhance anti-tumor response in combination with targeted
anti-cancer antibodies and checkpoint inhibitors with no adverse effect
on CD47-expressing normal blood cells. ALX148 is currently being
investigated in a phase 1 study in combination with checkpoint
inhibitors and targeted anti-cancer antibodies (NCT03013218).

About Alexo Therapeutics
Alexo Therapeutics is a
clinical-stage immuno-oncology company developing therapies that block
the CD47 checkpoint mechanism, which is exploited by cancer cells to
evade the immune system. Our lead candidate, ALX148, is a fusion protein
comprised of an engineered high affinity CD47 binding domain of SIRPα
linked to an inactive Fc region of human immunoglobulin. ALX148 is
designed to enhance the efficacy of antibody-based therapies and is in
clinical development for a broad range of tumor types. www.alexotherapeutics.com



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