Hepatitis C reinfection after DAAs highest among recent injection drug users

Hepatitis C reinfection after DAAs highest among recent injection drug users

Reinfection with hepatitis C after direct-acting antiviral (DAA) therapy is highest in people with recent injection drug use, according to a recent study published in the Journal of Hepatology. However, among people who inject drugs, daily use of opioid-agonist therapy was associated with a lower risk of reinfection. “Direct-acting antiviral therapies are an important tool […]

'Latent' Tuberculosis? It's Not That Common, Experts Find

'Latent' Tuberculosis? It's Not That Common, Experts Find

Although experts frequently assert that nearly 1.7 billion people carry dormant tuberculosis worldwide, that figure may be a “gross exaggeration” of the real threat, a recent study concludes. The study, published last month in the journal BMJ, found that nearly everyone who falls seriously ill with TB does so within two years of getting infected. […]

NIH launches study to test combination antibody treatment for HIV infection

NIH launches study to test combination antibody treatment for HIV infection

News Release Thursday, September 20, 2018 A clinical trial testing infusions of combination antibodies in people living with HIV has begun at the National Institutes of Health. The early phase clinical trial will evaluate whether periodic infusions of two highly potent, HIV-specific, broadly neutralizing antibodies (bNAbs)—3BNC117 and 10-1074—are safe in people living with HIV. The […]

Pre-sex HIV drug should be made available on NHS, MPs say

Pre-sex HIV drug should be made available on NHS, MPs say

Image copyright Getty Images A drug that cuts the chances of contracting HIV during sex should be made available on the NHS in England to anyone at risk, three MPs have told the BBC’s Victoria Derbyshire programme. Tory MPs Crispin Blunt and Nigel Evans, and Labour’s Stephen Doughty said the Prep drug had been proven […]

Community delivery of antiretroviral drugs: A non-inferiority cluster-randomized pragmatic trial in Dar es Salaam …

Community delivery of antiretroviral drugs: A non-inferiority cluster-randomized pragmatic trial in Dar es Salaam …

Citation: Geldsetzer P, Francis JM, Sando D, Asmus G, Lema IA, Mboggo E, et al. (2018) Community delivery of antiretroviral drugs: A non-inferiority cluster-randomized pragmatic trial in Dar es Salaam, Tanzania. PLoS Med 15(9): e1002659. https://doi.org/10.1371/journal.pmed.1002659 Academic Editor: Marie-Louise Newell, University of Southampton, UNITED KINGDOM Received: May 7, 2018; Accepted: August 23, 2018; Published: September […]

Recon: NICE Rejects Novartis' CAR-T Kymriah for Adults; CA Insurance Regulator Sues AbbVie Over Alleged Humira …

Recon: NICE Rejects Novartis' CAR-T Kymriah for Adults; CA Insurance Regulator Sues AbbVie Over Alleged Humira …

Posted 19 September 2018 | By Michael Mezher  Welcome to Regulatory Reconnaissance, your daily regulatory news and intelligence briefing.   In Focus: US California insurance regulator sues AbbVie alleging Humira kickbacks (Reuters) (STAT) (Endpoints) (Financial Times) Clovis Oncology, execs to pay $20 million to settle SEC charges (Reuters) (Endpoints) In unlikely alliance, […]

Truvada ruling could allow cheap HIV prevention in the UK

Truvada ruling could allow cheap HIV prevention in the UK

Cheap copies of Gilead’s HIV drug Truvada, which can also be used to reduce the risk of people becoming infected, could be available in the UK following a court ruling. Truvada (tenofovir disoproxil+emtricitabine) is used as the backbone of many HIV combination therapies, and the decision paves the way for much cheaper therapies for people […]

US doctors' organisation endorses event-based PrEP for the first time

US doctors' organisation endorses event-based PrEP for the first time

For the first time, a US-based professional HIV body has published guidelines endorsing event-based or so-called ‘on-demand’ pre-exposure prophylaxis (PrEP) as an alternative to daily dosing. The International Antiviral Society-USA (IAS-USA) released its 2018 recommendations during the International AIDS Conference in Amsterdam, but there was not much comment on their significance at the time. Bodies […]