Engineered enzyme eliminates nicotine addiction in preclinical tests

Engineered enzyme eliminates nicotine addiction in preclinical tests

La Jolla, CA – Oct. 17, 2018 – Scientists at Scripps Research have successfully tested a potential new smoking-cessation treatment in rodents. In a study published online in Science Advances on Oct. 17, 2018, the scientists gave nicotine-dependent rats an engineered enzyme that breaks down nicotine in the bloodstream before it can reach the brain. […]

Blood pressure drug could treat Parkinson's, iPS cell study finds

Blood pressure drug could treat Parkinson's, iPS cell study finds

Japanese research using induced pluripotent stem (iPS) cell technology has brought new hope to Parkinson’s disease patients with the discovery that an existing drug for high blood pressure could also be effective on their condition. The findings were published in U.S. science journal Stem Cell Reports on Oct. 18. The joint research team included a […]

A 150-Year-Old Drug Could Improve One of The Biggest Problems With Radiation Therapy

A 150-Year-Old Drug Could Improve One of The Biggest Problems With Radiation Therapy

A muscle relaxant drug, discovered 150 years ago, may have a new role to play in modern medicine.  New research suggests that the drug, called papaverine, could give a much-needed boost to radiation therapy, increasing its impact on cancerous cells in hard-to-reach areas.   Radiation therapy kills malignant cells by damaging their DNA. While this approach […]

$11 million NIH grant creates new center for musculoskeletal research at Clemson

$11 million NIH grant creates new center for musculoskeletal research at Clemson

CLEMSON, South Carolina – With an $11 million grant from the National Institutes of Health Center for Biomedical Research Excellence, Clemson University has launched the South Carolina Center for Translational Research Improving Musculoskeletal Health, or SC-TRIMH, a new research center that will bring together scientists from across South Carolina to change the way musculoskeletal disorders […]

Cryptographic protocol enables greater collaboration in drug discovery

Cryptographic protocol enables greater collaboration in drug discovery

MIT researchers have developed a cryptographic system that could help neural networks identify promising drug candidates in massive pharmacological datasets, while keeping the data private. Secure computation done at such a massive scale could enable broad pooling of sensitive pharmacological data for predictive drug discovery. Datasets of drug-target interactions (DTI), which show whether candidate compounds […]

$11 million NIH grant creates new center for musculoskeletal research

$11 million NIH grant creates new center for musculoskeletal research

CLEMSON, South Carolina – With an $11 million grant from the National Institutes of Health Center for Biomedical Research Excellence, Clemson University has launched the South Carolina Center for Translational Research Improving Musculoskeletal Health, or SC-TRIMH, a new research center that will bring together scientists from across South Carolina to change the way musculoskeletal disorders […]

Disappointed but Undaunted: Pursuing New Avenues in Lupus Drug Development

Disappointed but Undaunted: Pursuing New Avenues in Lupus Drug Development

The march of scientific progress usually goes as follows: failure, failure, failure, failure, success, failure, failure, ad infinitum. Progress toward effective drug therapies often follows a similar pattern; yet even among the host of difficult to treat autoimmune diseases, systemic lupus erythematosus has received a disproportionate share of therapeutic setbacks and disappointing clinical trials, particularly […]

Artificial intelligence crowdsources data to speed up drug discovery

Artificial intelligence crowdsources data to speed up drug discovery

A new cryptographic system could allow pharmaceutical companies and academic labs to work together to develop new medications more quickly — without revealing any confidential data to their competitors. The centerpiece of this computing system is an artificial intelligence program known as a neural network. The AI studies information about which drugs interact with various […]